In a randomized controlled trial published in 2009 (abstract), intubated ICU patients who underwent oral/digestive decontamination had lower mortality than control patients. However, a follow-up study from this trial shows that the the point prevalence of resistant gram-negative colonization rates were higher after the intervention than before the intervention. This may give pause to those ICU’s considering routine decontamination protocols, and further long-term follow-up of clinical outcomes from this study will be interesting (abstract).

This entry was posted on Thursday, April 1st, 2010 at 12:19 pm and is filed under ID, Pulmonary and Critical Care. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.