In this single center retrospective cohort of 53,236 hospitalizations, hospital-acquired hyponatremia occurred in over 1/3 of patients, and was associated with an increased odds of in-hospital death (OR 1.7, CI 1.4-2), discharge to a facility (OR 1.6, CI 1.6-1.7), and longer length of stay (by 64%). Hospital acquired hyponatremia is common, and associated with higher mortality and LOS. A deeper understanding of the etiology and management of hyponatremia is needed, to help decrease the associated mortality and resource use (abstract).

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