In this prospective multi-center trial of 630 ICU patients, patients were randomized to pro-calcitonin guided antibiotics or usual care. The pro-calcitonin group had antibiotics started or stopped based on pre-determined pro-calcitonin levels. There was no difference in 28 or 60 day mortality between the groups, but days of antibiotics were less in the pro-calcitonin group (12 vs 14 days). Although this study did not show any difference in outcomes measures, antibiotic use can be reduced by the use of pro-calcitonin guided therapy (abstract).

This entry was posted on Monday, January 25th, 2010 at 10:56 am and is filed under ID, Pulmonary and Critical Care. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.