Linezolid salvage therapy for persistent MRSA bacteremia

In this small trial of 35 patients with persistent MRSA bacteremia (>7 days despite vancomycin treatment), those switched to linezolid had much higher response (negative cultures at 72 hours) than those continued on vancomycin + aminoglycosides or rifampin (75% versus 17%). Patients with persistent MRSA bacteremia despite vancomycin should be switched to linezolid, rather than adding adjuvant treatment to vancomycin (abstract)