Peri-procedural bleeding with dabigatran versus warfarin

In this analysis from the RELY trial, the risk of periprocedural bleeding was compared between those on warfarin and those on dabigatran (from 7 days before to 30 days after an invasive procedure). Dabigatran was interrupted a mean of 49 hours before the procedures, and warfarin for 114 hours. There was no significant difference in major bleeding rates between dabigatran (150mg dose) and warfarin, which occurred in 5.1% versus 4.6% respectively. Warfarin and dabigatran have about the same rate of periprocedural bleeding rates, but interruption duration is shorter for dabigatran (abstract)