Category Archives: Neurology
This randomized trial found induced hypothermia was associated with higher mortality in patients with bacterial meningitis (compared to standard care) (abstract).
This cohort of patients with new onset seizures found epileptogenic foci in 28% of patients with true seizures (abstract).
In this cohort of ICU patients, 3/4 developed ICU delirium; at 3 months 40% had cognition scores 1.5 SD below the mean, and 25% were 2 SD below the mean. By 12 months, ~1/3 had scores similar to mild traumatic … Continue reading
This large derivation and validation cohort of >50,000 in-hospital arrest patients found a 13-variable model was able to identify ~25% of patients whose outcomes were highly unlikely to be good (survival to discharge with good neurologic function); this can be … Continue reading
This large prospective cohort found thrombolytics given within 90 minutes of stroke symptom onset had 1.5 times the odds of a 3-month Rankin score of 0 or 1, compared to longer times (abstract).
In this derivation and validation cohort, 4 factors independently predicted the risk of developing delirium: age>80, unable to spell “WORLD” backwards, disoriented to place, and higher nurse-rated illness severity. Rates of delirium for scores 0-4 were 2%, 4%, 14%, 20% … Continue reading
In this large multicenter trial, patients with minor stroke or TIA were randomized to clopidogrel+ASA or ASA alone; 90-day stroke occurred in 8% vs 12% respectively, and rates of hemorrhage or hemorrhagic stroke were the same (abstract).
These guidelines provide an evidence based for the use of periprocedural antithrombotics in patients with cerebrovascular disease. They recommend continuing ASA-warfarin for dental procedures, and most other minor procedures. There is little evidence to support the use of procedural bridging … Continue reading
A large analysis from a stroke registry found better outcomes with earlier thrombolytics for acute ischemic stroke; every 15 minutes earlier was associated with an odds ratio of 0.96 for in-hospital death or intracranial hemorrhage, and an odds ratio of … Continue reading