Category Archives: ID

Hypothermia not helpful in bacterial meningitis

This randomized trial found induced hypothermia was associated with higher mortality in patients with bacterial meningitis (compared to standard care) (abstract).

Posted in ID, Neurology | Comments Off

RSV in adults

This study compared morbidity and mortality in adults hospitalized with RSV or influenza and found overall length of stay and mortality were not significantly different between the 2 infections (with 30 day mortality at 9%) (abstract).

Posted in ID, Influenza | Comments Off

Gloves and Gown for all ICU patients?

This large trial randomized ICUs to gloves/gowns for all patients, or usual care, and found no difference in MRSA-VRE acquisition (abstract).

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Too many urine cultures

This single site retrospective analysis found 58% of patients with a urinary culture did not fit evidence based criteria to have the culture sent; reducing unnecessary testing is an opportunity to reduce hospital acquired UTI rates (abstract).

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De-escalation of antibiotics in sepsis

This prospective analysis of sepsis patients found those that had antibiotics appropriately de-escalated had lower mortality than those that did not (OR 0.55) (abstract).

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Tigecycline black box warning for higher mortality

Due to the black box warning of higher mortality compared to other antibiotics, tigecycline should be reserved only for use when other safer antibiotics are not feasible (FDA warning).

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Top ID threats

The CDC released a report on the top infectious threats, the top 3 of which were Cdiff, drug-resistant gonorrhea, and carbapenem-resistant enterobacteriaeae. All told, drug-resistant organisms result in 2 million infections and 23,000 deaths per year (CDC report).

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Modern day MRSA infection rates

This large sample of 9 US metropolitan areas found that hospital acquired MRSA infections were reduced by 54% and community acquired MRSA infections were reduced by 5%, from 2005 to 2011 (abstract).

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Readmit rates for HIV

This large cohort found 30 day readmit rates for HIV patients to be 19% overall, and 26% in those with CD4<50. Risks for readmissions included low CD4, longer LOS, AIDS-defining infections, cancer, and GI-metabolic-neurology diagnoses (abstract).

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IV iron reduces transfusions, but increases infections

This systematic review found IV iron infusions increased hemoglobin and reduced the need for blood transfusions, but increased the risk of infections (relative risk 1.3, CI 1.1 to 1.6) (abstract).

Posted in Hematology and Oncology, ID | Comments Off