Category Archives: GI
Managing coagulation in cirrhotics is very difficult. A new practical guideline gives the following advice: For invasive procedures, keep platelets >50K, avoid FFP, and consider ddavp for dental extractions; for bleeding varices, also keep Hb around 7, and keep fibrinogen … Continue reading
This trial randomized patients with acute alcoholic hepatitis to prednisolone +/- pentoxifylline and found no difference in outcomes between the groups (abstract)
This meta-analysis found no significant differences in outcomes (rebleeding, surgery, transfusion, or mortality) among patients with bleeding PUD on either oral or IV PPIs. However, the trials included were low overall quality, so best to wait for a randomized trial … Continue reading
This large trial of ~3,000 patients age 65+ on 1 or more antibiotics randomized them to lactobacilli and bifidobacteria for 8 weeks, and found no significant difference in diarrhea or Cdiff between the groups (abstract).
In this study of patients with UGIB, researchers compared the Glasgow-Blatchford and Rockall scores in predicting outcomes with UGIB; they found the GBS was equivalent to the RS for predicting rebleeding, need for endoscopy, or death, but was better than … Continue reading
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a … Continue reading
The American Association for the Study of Liver Disease has released guidelines on the management of ascites. Among the recommendations, some include: use caution when prescribing agents that lower arterial blood pressure (such as ACE/ARBs), avoid the vaptan drugs, and … Continue reading
This online risk calculator can help clinicians weigh the risks and benefits of ASA for individual patients (calculator).